Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13301181 | 0.98 | MMP1 (0.38) | MMP1MMP7MMP12ECE1MMP13 | |
| SCHEMBL805007 | 0.90 | — | — | |
| SCHEMBL1704325 | 0.82 | CA1 (0.46) | MMP1MMP7MMP12ECE1MMP13 | |
| SCHEMBL24269616 | 0.80 | MAOB (0.32) | — | |
| SCHEMBL1703764 | 0.80 | CA1 (0.44) | MMP1MMP7MMP12ECE1MMP13 | |
| SCHEMBL20550163 | 0.78 | THRB (0.36) | BRD4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23181217 | 0.77 | CA1 (0.48) | MMP1MMP7MMP12ECE1MMP13 | |
| SCHEMBL26864669 | 0.76 | SMN1; SMN2 (0.33) | MMP1MMP7MMP12ECE1MMP13 | |
| SCHEMBL25856620 | 0.75 | — | — | |
| SCHEMBL21210675 | 0.74 | OPRM1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022068848-A1 | 3-[(1H-PYRAZOL-4-YL)OXY]PYRAZIN-2-AMINE COMPOUNDS AS HPK1 INHIBITOR AND USE THEREOF | BEIGENE, LTD. (KY) | 2022-04-07 | — | — | WO | disclosed |
| WO-1996024591-A1 | CYCLOALKYLSULPHONYL-AMINOSULPHONYL UREAS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-15 | — | — | WO | disclosed |