Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 4/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8934852 | 1.00 | POLB (0.35) | POLBALDH1A1KDM4EGAANR1H4 | |
| Oxalic Acid SCHEMBL8795918 | 0.90 | MAOB (0.35) | ALDH1A1KDM4EGAAKMT2AMAOB | |
| Oxalic Acid SCHEMBL8795914 | 0.90 | MAOB (0.35) | ALDH1A1KDM4EGAAKMT2AMAOB | |
| Oxalic Acid SCHEMBL8934783 | 0.90 | MAPT (0.34) | POLBALDH1A1KDM4EGAASMN1; SMN2 | |
| Oxalic Acid SCHEMBL7987278 | 0.79 | KMT2A (0.41) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAOB | |
| Oxalic Acid SCHEMBL7987283 | 0.79 | KMT2A (0.41) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAOB | |
| SCHEMBL8794353 | 0.77 | MAOB (0.47) | POLBALDH1A1KDM4ESMN1; SMN2KMT2A | |
| Oxalic Acid SCHEMBL7991119 | 0.77 | SMN1; SMN2 (0.40) | POLBALDH1A1KDM4EGAASMN1; SMN2 | |
| Oxalic Acid SCHEMBL7988233 | 0.75 | HRH3 (0.41) | POLBALDH1A1KMT2ARAB9AMAOB | |
| SCHEMBL4543078 | 0.74 | PRSS1 (0.38) | ALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |