Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568990 | 1.00 | LMNA (0.49) | LMNAKDM4ESMN1; SMN2ALDH1A1LTB4R | |
| SCHEMBL5512458 | 0.89 | KDM4E (0.53) | LMNAKDM4ESMN1; SMN2ALDH1A1IRAK4 | |
| SCHEMBL6780384 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LTB4RMAPTPPARA | |
| SCHEMBL8935641 | 0.80 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2ALDH1A1PPARAPPARG | |
| SCHEMBL8935961 | 0.80 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2LTB4RMAPTL3MBTL1 | |
| SCHEMBL4650644 | 0.80 | KMT2A (0.62) | LMNASMN1; SMN2ALDH1A1L3MBTL1PPARA | |
| SCHEMBL17633012 | 0.80 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2LTB4RMAPTPPARA | |
| SCHEMBL3879629 | 0.80 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2ALDH1A1PPARAPPARG | |
| SCHEMBL8935639 | 0.80 | KMT2A (0.62) | LMNASMN1; SMN2ALDH1A1L3MBTL1PPARA | |
| SCHEMBL27479098 | 0.80 | IRAK4 (0.53) | LMNAKDM4ESMN1; SMN2ALDH1A1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |