Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118331 | 0.80 | TNKS2 (0.46) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8936191 | 0.78 | GRIN2D (0.39) | GPR17GAAKDM4EALDH1A1HPGD | |
| SCHEMBL29770446 | 0.77 | ALDH1A1 (0.59) | GAAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL4045859 | 0.77 | ALDH1A1 (0.59) | GAAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL13264599 | 0.75 | KDM4E (0.62) | GAAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8936072 | 0.73 | SMN1; SMN2 (0.38) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4112701 | 0.72 | GPR84 (0.42) | KDM4ESMN1; SMN2GLATP53TNKS2 | |
| SCHEMBL8936160 | 0.72 | GRIN2D (0.43) | KDM4EALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL29792700 | 0.71 | LMNA (0.47) | ALDH1A1HPGDNPSR1SMN1; SMN2KMT2A | |
| SCHEMBL13326518 | 0.71 | LMNA (0.47) | ALDH1A1HPGDNPSR1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |