Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853429 | 0.78 | NR1H2 (0.47) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL20462815 | 0.75 | TDP1 (0.50) | LMNAKMT2ATDP1 | |
| SCHEMBL8936654 | 0.72 | TP53 (0.45) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL9853427 | 0.72 | TP53 (0.48) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL8936730 | 0.72 | TP53 (0.53) | TP53MAPTPOLBKMT2AMEN1 | |
| SCHEMBL8936648 | 0.72 | TP53 (0.45) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL9101435 | 0.72 | TP53 (0.60) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL8936630 | 0.71 | TP53 (0.51) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL29459229 | 0.70 | TDP1 (0.65) | TP53LMNAPOLBTDP1 | |
| SCHEMBL6127956 | 0.70 | TDP1 (0.65) | TP53LMNAPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547951-A | ENZYME INHIBITORS; AIDS | BOEHRINGER INGELHEIM PHARAMCEUTICALS, INC. (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0417534-A1 | Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and thiones and their use in the prevention or treatment of AIDS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1991-03-20 | — | — | EP | disclosed |