Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936707 | 0.89 | CYP19A1 (0.40) | CYP19A1CYP11B1SLC6A4KEAP1TSHR | |
| SCHEMBL8936708 | 0.79 | CYP19A1 (0.40) | CYP19A1CYP11B1SLC6A4KEAP1TSHR | |
| SCHEMBL8936776 | 0.79 | SLC6A4 (0.46) | CYP19A1CYP11B1SLC6A4KEAP1TSHR | |
| SCHEMBL8884360 | 0.73 | CYP19A1 (0.60) | CYP19A1CYP11B1SLC6A4KEAP1KMT2A | |
| SCHEMBL9523659 | 0.70 | CYP19A1 (0.50) | CYP19A1CYP11B1SLC6A4KEAP1KMT2A | |
| SCHEMBL30235581 | 0.70 | KEAP1 (0.43) | KEAP1 | |
| SCHEMBL14476937 | 0.67 | KEAP1 (0.53) | CYP19A1CYP11B1SLC6A4KEAP1KMT2A | |
| SCHEMBL18322394 | 0.67 | NFE2L2 (0.38) | KEAP1 | |
| SCHEMBL17494783 | 0.66 | BACE1 (0.33) | KMT2A | |
| SCHEMBL17494744 | 0.66 | TDP1 (0.41) | SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587392-A | THERAPY FOR ESTROGEN DEPENDENT DISEASES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0684235-A1 | Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-29 | — | — | EP | disclosed |