Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936703 | 0.89 | CYP19A1 (0.41) | CYP19A1CYP11B1SLC6A4KEAP1FAAH | |
| SCHEMBL8936776 | 0.78 | SLC6A4 (0.46) | CYP19A1CYP11B1SLC6A4KEAP1FAAH | |
| SCHEMBL18322394 | 0.76 | NFE2L2 (0.38) | KEAP1NFE2L2 | |
| SCHEMBL9026711 | 0.74 | CYP19A1 (0.58) | CYP19A1CYP11B1SLC6A4KEAP1FAAH | |
| SCHEMBL17494783 | 0.72 | BACE1 (0.33) | KMT2AKDM4EMEN1 | |
| SCHEMBL30235581 | 0.71 | KEAP1 (0.43) | KEAP1NFE2L2 | |
| SCHEMBL8936708 | 0.69 | CYP19A1 (0.40) | CYP19A1CYP11B1SLC6A4KEAP1TSHR | |
| SCHEMBL18322427 | 0.69 | NFE2L2 (0.37) | KEAP1NFE2L2 | |
| SCHEMBL14476937 | 0.67 | KEAP1 (0.53) | CYP19A1CYP11B1SLC6A4KEAP1FAAH | |
| SCHEMBL5373425 | 0.66 | MEN1 (0.49) | SLC6A4KMT2ATSHRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587392-A | THERAPY FOR ESTROGEN DEPENDENT DISEASES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0684235-A1 | Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-29 | — | — | EP | disclosed |