SCHEMBL8936797

SCHEMBL8936797

CNc1cc(Oc2ccc(Cl)cc2Cn2cncn2)ccc1N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.41
SLC6A4 P31645 3/20 0.41
KCNH2 Q12809 3/20 0.41
CYP19A1 P11511 7/20 0.41
CCR1 P32246 1/20 0.40
CCR2 P41597 1/20 0.40
CCR4 P51679 1/20 0.40
SCN9A Q15858 1/20 0.37
POLB P06746 1/20 0.37
NLRP3 Q96P20 1/20 0.36
MAPK1 P28482 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
STS P08842 1/20 0.35
F2 P00734 1/20 0.35
F10 P00742 1/20 0.35
MAPT P10636 2/20 0.35
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8936701 0.90 CCR1 (0.39) HTR2ASLC6A4KCNH2CYP19A1CCR1
SCHEMBL8936697 0.88 SLC6A4 (0.39) HTR2ASLC6A4KCNH2CYP19A1SCN9A
SCHEMBL8936749 0.87 CYP19A1 (0.40) HTR2ASLC6A4KCNH2CYP19A1CCR1
SCHEMBL8936779 0.85 SLC6A4 (0.42) HTR2ASLC6A4KCNH2CYP19A1SCN9A
SCHEMBL8936771 0.84 TDP1 (0.41) HTR2ASLC6A4KCNH2CYP19A1CCR1
SCHEMBL8936690 0.82 MEN1 (0.47) HTR2ASLC6A4KCNH2CYP19A1MEN1
SCHEMBL8936735 0.78 PDE7A (0.45) CYP19A1CCR1CCR2CCR4SCN9A
SCHEMBL8936793 0.78 CCR1 (0.40) CYP19A1CCR1CCR2CCR4POLB
SCHEMBL8936782 0.77 CYP19A1 (0.40) HTR2ASLC6A4KCNH2CYP19A1CCR1
SCHEMBL8936766 0.76 MAPT (0.41) HTR2ASLC6A4KCNH2CYP19A1CCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5587392-A THERAPY FOR ESTROGEN DEPENDENT DISEASES MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1996-12-24 US disclosed
EP-0684235-A1 Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1995-11-29 EP disclosed