SCHEMBL8937142

SCHEMBL8937142

C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@]2(O)[Na]

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STS P08842 13/20 0.78
ESR1 P03372 4/20 0.75
CYP3A4 P08684 2/20 0.75
ESR2 Q92731 2/20 0.75
ABCB11 O95342 2/20 0.75
SLC22A2 O15244 1/20 0.75
NR1I2 O75469 1/20 0.75
NR3C1 P04150 1/20 0.75
SHBG P04278 1/20 0.75
PGR P06401 1/20 0.75
HTR1A P08908 1/20 0.75
ADORA3 P0DMS8 1/20 0.75
AR P10275 1/20 0.75
ADRB3 P13945 1/20 0.75
CYP2B6 P20813 1/20 0.75
TBXA2R P21731 1/20 0.75
UGT1A1 P22309 1/20 0.75
SLC6A2 P23975 1/20 0.75
PDE4A P27815 1/20 0.75
ADORA2A P29274 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19393201 0.88 STS (1.00) STSESR1CYP3A4ESR2ABCB11
SCHEMBL13266169 0.88 STS (1.00) STSESR1CYP3A4ESR2ABCB11
SCHEMBL3867797 0.88 STS (1.00) STSESR1CYP3A4ESR2ABCB11
SCHEMBL5336088 0.88 STS (0.81) STSESR1CYP3A4ESR2ABCB11
SCHEMBL5324130 0.88 STS (1.00) STSESR1CYP3A4ESR2ABCB11
SCHEMBL17775797 0.86 STS (0.79) STSESR1CYP3A4ESR2ABCB11
Ethinyl Estradiol SCHEMBL19963467 0.86 ESR1 (1.00) STSESR1CYP3A4ESR2ABCB11
Ethinyl Estradiol SCHEMBL7602883 0.86 ESR1 (1.00) STSESR1CYP3A4ESR2ABCB11
Ethinyl Estradiol SCHEMBL5030184 0.86 ESR1 (1.00) STSESR1CYP3A4ESR2ABCB11
Ethinyl Estradiol SCHEMBL4071 0.86 ESR1 (1.00) STSESR1CYP3A4ESR2ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0655924-A4 A COMBINATION OF ANTI-erbB-2 MONOCLONAL ANTIBODIES AND METHOD OF USING. ONCOLOGIX INC (US) 1996-09-11 EP disclosed
EP-0655924-A1 A COMBINATION OF ANTI-erbB-2 MONOCLONAL ANTIBODIES AND METHOD OF USING ONCOLOGIX, INC. (US) 1995-06-07 EP disclosed
WO-1994000136-A1 A COMBINATION OF ANTI-erbB-2 MONOCLONAL ANTIBODIES AND METHOD OF USING ONCOLOGIX, INC. (US) 1994-01-06 WO disclosed