Indene

Indene

SCHEMBL89373

C1=Cc2ccccc2C1.CC(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Indene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.51
CYP2C19 P33261 1/20 0.51
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
NOTUM Q6P988 4/20 0.39
HSD17B3 P37058 2/20 0.39
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
PARP1 P09874 1/20 0.34
SRD5A2 P31213 2/20 0.33
MTNR1A P48039 1/20 0.33
MTNR1B P49286 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
SRD5A1 P18405 1/20 0.33
NAPRT Q6XQN6 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indene SCHEMBL29746662 1.00 CYP2D6 (0.51) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL27887053 0.98 CYP2D6 (0.50) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL28769797 0.98 CYP2D6 (0.50) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL28869263 0.94 CYP2D6 (0.49) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL6700608 0.92 CA2 (0.47) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL30959780 0.92 CA2 (0.47) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL2769732 0.89 CYP2D6 (0.53) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL5689989 0.89 CYP2D6 (0.53) CYP2D6CYP2C19CA1CA2HSD17B3
Indene SCHEMBL28216169 0.87 CA1 (0.50) CYP2D6CYP2C19CA1CA2NOTUM
Indene SCHEMBL27563612 0.87 CA1 (0.53) CYP2D6CYP2C19CA1CA2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4111 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240216311-A1 FULLY-DILUTABLE, SELF-MICROEMULSIFYING DELIVERY SYSTEMS (SMEDDS) FOR POORLY WATER-SOLUBLE POLAR SOLUTES THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2024-07-04 US claimed
WO-2024044849-A1 DILUTABLE COMPOSITIONS AND PROCESSES FOR EXTRACTING AND REFINING POORLY WATER-SOLUBLE POLAR OILS FROM BIOMASS MICELLAE DELIVERY SYSTEMS INC. (CA) 2024-03-07 WO claimed
US-20230405003-A1 APPLICATION OF THYMIDINE DERIVATIVE IN PREPARATION OF DRUGS ONQUALITY PHARMACEUTICALS CHINA LTD. (CN) 2023-12-21 US claimed
EP-4271414-A1 FULLY-DILUTABLE, SELF-MICROEMULSIFYING DELIVERY SYSTEMS (SMEDDS) FOR POORLY WATER-SOLUBLE POLAR SOLUTES The Governing Council of the University of Toronto (CA) 2023-11-08 EP claimed
EP-4238571-A1 APPLICATION OF THYMIDINE DERIVATIVE IN PREPARATION OF DRUGS OnQuality Pharmaceuticals China Ltd. (CN) 2023-09-06 EP claimed
WO-2022140843-A1 FULLY-DILUTABLE, SELF-MICROEMULSIFYING DELIVERY SYSTEMS (SMEDDS) FOR POORLY WATER-SOLUBLE POLAR SOLUTES THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2022-07-07 WO claimed
EP-3512503-A1 LIPOSOMAL FORMULATIONS Nanyang Technological University (SG) 2019-07-24 EP claimed
US-20190216735-A1 LIPOSOMAL FORMULATIONS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2019-07-18 US claimed
US-10076641-B2 Methods and systems for delivering substances into luminal walls THE SPECTRANETICS CORPORATION (US) 2018-09-18 US claimed
WO-2018052373-A1 LIPOSOMAL FORMULATIONS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2018-03-22 WO claimed
EP-1592386-A2 COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS Elan Pharmaceuticals, Inc. (US) 2005-11-09 EP claimed
EP-1592387-A2 COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS Elan Pharmaceuticals, Inc. (US) 2005-11-09 EP claimed
US-20050215565-A1 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents BIOGEN MA INC. 2005-09-29 US claimed
US-20050069541-A1 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents BIOGEN IDEC INTERNATIONAL HOLDING LTD. (BM) 2005-03-31 US claimed
WO-2004066932-A2 COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS ELAN PHARMACEUTICALS INC. (US) 2004-08-12 WO claimed
WO-2004066931-A2 COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS ELAN PHARMACEUTICALS INC. (US) 2004-08-12 WO claimed
US-20030212123-A1 COX-2 selective carprofen for treating pain and inflammation in dogs PFIZER INC. 2003-11-13 US claimed
US-20030176421-A1 PROKINETIC AGENTS FOR TREATING GASTRIC HYPOMOTILITY AND RELATED DISORDERS WATSON JOHN W (US) 2003-09-18 US claimed
EP-0642336-A1 USE OF NSIAD IN THE TREATMENT OF DEMENTIA UNIVERSITY OF BRITISH COLUMBIA (CA) 1995-03-15 EP claimed
WO-1993024115-A1 ANTI-RHEUMATOID ARTHRITIC DRUGS IN THE TREATMENT OF DEMENTIA THE UNIVERSITY OF BRITISH COLUMBIA (CA) 1993-12-09 WO claimed