Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 9/20 | 0.48 |
| ▸ | TUBB | P07437 | 9/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 9/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 9/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 9/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 9/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 9/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 9/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 9/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 9/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 9/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 9/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937380 | 1.00 | KRAS (0.56) | KRASSMN1; SMN2ALDH1A1ATML3MBTL1 | |
| SCHEMBL8937472 | 1.00 | KRAS (0.56) | KRASSMN1; SMN2ALDH1A1ATML3MBTL1 | |
| SCHEMBL8937441 | 0.80 | PKM (0.62) | SMN1; SMN2ALDH1A1L3MBTL1KDM4EGAA | |
| SCHEMBL8937437 | 0.80 | PKM (0.62) | SMN1; SMN2ALDH1A1L3MBTL1KDM4EGAA | |
| SCHEMBL8937580 | 0.80 | PKM (0.62) | SMN1; SMN2ALDH1A1L3MBTL1KDM4EGAA | |
| SCHEMBL3165945 | 0.79 | CES2 (0.52) | ALDH1A1MAPTTNFRSF1A | |
| SCHEMBL9367554 | 0.79 | CA12 (0.62) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL8937622 | 0.78 | PKM (0.64) | SMN1; SMN2ALDH1A1L3MBTL1KDM4EGAA | |
| SCHEMBL28718474 | 0.77 | ALDH1A1 (0.47) | KRASSMN1; SMN2ALDH1A1ATML3MBTL1 | |
| SCHEMBL5962285 | 0.77 | CA12 (0.65) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |