Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937539 | 0.91 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1TP53SMN1; SMN2POLB | |
| SCHEMBL8937252 | 0.89 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL8937259 | 0.89 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL8937620 | 0.79 | ALDH1A1 (0.79) | ALDH1A1L3MBTL1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL8937485 | 0.78 | L3MBTL1 (0.49) | ALDH1A1L3MBTL1MAPTNPSR1TP53 | |
| SCHEMBL8937244 | 0.75 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1MEN1KMT2ATP53 | |
| SCHEMBL8937251 | 0.75 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1MEN1KMT2ATP53 | |
| SCHEMBL8937249 | 0.75 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1MEN1KMT2ATP53 | |
| SCHEMBL8937440 | 0.74 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL8937435 | 0.74 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1NPSR1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |