Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.55 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.55 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937507 | 1.00 | KMT2A (0.61) | KMT2AMEN1ALDH1A1CYP19A1CYP11B2 | |
| SCHEMBL8937512 | 1.00 | KMT2A (0.61) | KMT2AMEN1ALDH1A1CYP19A1CYP11B2 | |
| SCHEMBL63954 | 0.87 | CES1 (0.50) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28141157 | 0.86 | BCAT2 (0.43) | KMT2AMEN1ALDH1A1CYP19A1CYP11B2 | |
| Hydrochloric Acid SCHEMBL4398755 | 0.85 | NFE2L2 (0.48) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28638888 | 0.83 | KMT2A (0.49) | KMT2AMEN1ALDH1A1CYP19A1NAPRT | |
| Hydrochloric Acid SCHEMBL6167657 | 0.82 | TBXAS1 (0.59) | ALDH1A1CYP19A1CYP11B2PLOD2TBXAS1 | |
| Hydrochloric Acid SCHEMBL6166969 | 0.82 | TBXAS1 (0.59) | ALDH1A1CYP19A1CYP11B2PLOD2TBXAS1 | |
| Hydrochloric Acid SCHEMBL6166975 | 0.82 | TBXAS1 (0.59) | ALDH1A1CYP19A1CYP11B2PLOD2TBXAS1 | |
| SCHEMBL16464023 | 0.82 | HCAR2 (0.53) | KMT2AMEN1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |