Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938362 | 0.90 | HTR1A (0.44) | OPRD1OPRM1 | |
| SCHEMBL8938187 | 0.89 | CCR5 (0.47) | HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8938400 | 0.89 | HRH3 (0.44) | OPRD1HRH3CHRM3 | |
| SCHEMBL8938422 | 0.87 | OPRD1 (0.44) | OPRD1OPRM1HRH3CHRM3 | |
| SCHEMBL8938509 | 0.86 | BCHE (0.45) | HRH3GRM5GRM7GRM3 | |
| SCHEMBL8938541 | 0.86 | OPRD1 (0.46) | OPRD1GRM5GRM7GRM3ALDH1A1 | |
| SCHEMBL8938317 | 0.84 | HRH3 (0.40) | OPRM1HRH3 | |
| SCHEMBL8938550 | 0.84 | HTR2A (0.48) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8938356 | 0.84 | CCR5 (0.46) | HRH3ALDH1A1 | |
| SCHEMBL8938514 | 0.83 | HRH3 (0.42) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |