Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 9/20 | 0.68 |
| ▸ | TUBB | P07437 | 9/20 | 0.68 |
| ▸ | TUBA3C | P0DPH7 | 9/20 | 0.68 |
| ▸ | TUBA1B | P68363 | 9/20 | 0.68 |
| ▸ | TUBA4A | P68366 | 9/20 | 0.68 |
| ▸ | TUBB4B | P68371 | 9/20 | 0.68 |
| ▸ | TUBB3 | Q13509 | 9/20 | 0.68 |
| ▸ | TUBB2A | Q13885 | 9/20 | 0.68 |
| ▸ | TUBB8 | Q3ZCM7 | 9/20 | 0.68 |
| ▸ | TUBA3E | Q6PEY2 | 9/20 | 0.68 |
| ▸ | TUBA1A | Q71U36 | 9/20 | 0.68 |
| ▸ | TUBA1C | Q9BQE3 | 9/20 | 0.68 |
| ▸ | TUBB6 | Q9BUF5 | 9/20 | 0.68 |
| ▸ | TUBB2B | Q9BVA1 | 9/20 | 0.68 |
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9589300 | 0.91 | TUBB4A (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8938336 | 0.86 | TUBB4A (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5798445 | 0.81 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8938463 | 0.79 | TUBB4A (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9986859 | 0.78 | ALDH1A1 (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2348081 | 0.76 | TUBB4A (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2348003 | 0.76 | TUBB4A (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5812186 | 0.75 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5808232 | 0.75 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14419949 | 0.74 | KDM4E (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527819-A | TREATING AIDS | MERCK & CO., INC. (US) | 1996-06-18 | — | — | US | disclosed |
| EP-0686148-A4 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0686148-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO. INC. (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0678508-A1 | Indoles as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1995-10-25 | — | — | EP | disclosed |
| WO-1994019321-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |
| WO-1993005020-A1 | INDOLES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-18 | — | — | WO | disclosed |
| EP-0530907-A1 | Indoles as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5124327-A | Administering in the prevention and treatment of AIDS | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | disclosed |