Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.65 |
| ▸ | MAP2 | P11137 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938451 | 0.84 | ALDH1A1 (0.68) | NHERF1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3091494 | 0.83 | KDM4E (0.66) | NHERF1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6756295 | 0.82 | KDM4E (0.65) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL9449420 | 0.81 | KDM4E (0.71) | ALDH1A1MAPTMEN1KMT2AMAP2 | |
| SCHEMBL2538695 | 0.81 | PRNP (0.69) | ALDH1A1MAPTMEN1KMT2ASIRT1 | |
| SCHEMBL16516496 | 0.79 | POLB (0.60) | ALDH1A1MAPTMEN1KMT2AMAP2 | |
| SCHEMBL4615348 | 0.79 | SIRT1 (0.62) | ALDH1A1MAPTMEN1KMT2ASIRT1 | |
| SCHEMBL9190459 | 0.79 | GPR17 (0.80) | ALDH1A1MAP2POLBKDM4EGPR17 | |
| SCHEMBL27644764 | 0.78 | MEN1 (0.59) | NHERF1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23511153 | 0.78 | ALDH1A1 (0.66) | NHERF1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577356-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2020-03-03 | — | — | US | disclosed |
| US-10577356-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2020-03-03 | — | — | US | disclosed |
| US-20190040045-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2019-02-07 | — | — | US | disclosed |
| US-20190040045-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2019-02-07 | — | — | US | disclosed |
| US-10118914-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2018-11-06 | — | — | US | disclosed |
| US-20170166554-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170166554-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170166554-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2017-06-15 | — | — | US | disclosed |
| WO-2015195486-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2015-12-23 | — | — | WO | disclosed |
| US-5527819-A | TREATING AIDS | MERCK & CO., INC. (US) | 1996-06-18 | — | — | US | disclosed |
| CN-1119856-A | Hiv reverse transcriptase inhibitors | MERCK & CO INC (US) | 1996-04-03 | — | — | CN | disclosed |
| EP-0686148-A4 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0686148-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO. INC. (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0678508-A1 | Indoles as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1995-10-25 | — | — | EP | disclosed |
| WO-1994019321-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |
| WO-1993005020-A1 | INDOLES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-18 | — | — | WO | disclosed |
| EP-0530907-A1 | Indoles as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166554-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | CNR1, CNR2, ARRB1 | NHERF1 2236/4885ALDH1A1 2372/4885MAPT 3519/4885 |
| US-10577356-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | CNR1, CNR2, ARRB1 | NHERF1 2236/4885ALDH1A1 2372/4885MAPT 3519/4885 |
| US-10118914-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | CNR1, CNR2, ARRB1 | NHERF1 2236/4885ALDH1A1 2372/4885MAPT 3519/4885 |
| US-20190040045-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | CNR1, CNR2, ARRB1 | NHERF1 2236/4885ALDH1A1 2372/4885MAPT 3519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.