Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.35 |
| ▸ | CCR3 | P51677 | 6/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937503 | 0.93 | HRH1 (0.35) | HRH1CCR3ADRA1DADRA1AADRA1B | |
| SCHEMBL8937316 | 0.89 | DRD2 (0.40) | HRH1CCR3PARP1DRD2SLC6A4 | |
| SCHEMBL8937313 | 0.87 | MAOA (0.42) | HRH1CCR3PARP1DRD2SLC6A4 | |
| SCHEMBL8937273 | 0.87 | HRH1 (0.38) | HRH1CCR3PARP1KCNH2RET | |
| SCHEMBL8937479 | 0.85 | PARP1 (0.41) | HRH1CCR3PARP1DRD2SLC6A4 | |
| SCHEMBL8937447 | 0.84 | HRH1 (0.37) | HRH1CCR3DRD2SLC6A4KCNH2 | |
| SCHEMBL8938999 | 0.83 | PARP1 (0.43) | HRH1CCR3PARP1KCNH2MAOA | |
| SCHEMBL8937388 | 0.83 | HRH1 (0.41) | HRH1CCR3KCNH2 | |
| SCHEMBL8937451 | 0.83 | HRH3 (0.43) | HRH1CCR3 | |
| SCHEMBL8939065 | 0.82 | HTR1A (0.37) | HRH1CCR3ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |