Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 6/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.35 |
| ▸ | CDK2 | P24941 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951836 | 0.80 | NPC1 (0.41) | PARP1METAP2METAP1GRIN2B | |
| SCHEMBL10600439 | 0.79 | NPC1 (0.43) | PARP1CYP2D6CYP2C9METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL6821628 | 0.79 | KDM4E (0.42) | PARP1METAP2METAP1GRIN2B | |
| SCHEMBL1375990 | 0.77 | METAP2 (0.41) | PARP1METAP2METAP1GRIN2B | |
| SCHEMBL19553769 | 0.77 | METAP2 (0.43) | PARP1POLBMETAP2METAP1GRIN2B | |
| SCHEMBL12921851 | 0.75 | PARP1 (0.49) | PARP1METAP2METAP1GRIN2B | |
| SCHEMBL2002532 | 0.73 | GRIN2B (0.46) | GRIN2B | |
| SCHEMBL4373720 | 0.72 | PARP1 (0.43) | PARP1METAP2METAP1GRIN2B | |
| SCHEMBL9854786 | 0.72 | GRIN2B (0.49) | GRIN2B | |
| SCHEMBL2388904 | 0.71 | GRIN2B (0.47) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574149-A | Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5-chlorouridine | GLAXO WELLCOME INC. (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0670328-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-09-06 | — | — | EP | disclosed |
| EP-0669341-A1 | Therapeutic Nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-30 | — | — | EP | disclosed |
| EP-0317128-A2 | Anti-HIV Pyrimidine Nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-05-24 | — | — | EP | disclosed |