Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 2/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204254 | 0.98 | CDK1 (0.65) | CDK1CDK2PDPK1HTTLMNA | |
| SCHEMBL6268103 | 0.77 | CDK2 (1.00) | CDK1CDK2PDPK1HTTLMNA | |
| SCHEMBL9199779 | 0.74 | CDK2 (0.86) | CDK1CDK2PDPK1HTTLMNA | |
| SCHEMBL9204849 | 0.74 | JAK3 (0.56) | CDK1CDK2HTTLMNAPAK1 | |
| SCHEMBL9682544 | 0.74 | CDK1 (0.63) | CDK1CDK2PDPK1MAP3K5CCNB1 | |
| SCHEMBL9204246 | 0.73 | JAK3 (0.58) | CDK1CDK2HTTLMNAPAK1 | |
| SCHEMBL7834228 | 0.72 | CDK1 (0.46) | CDK1CDK2PDPK1HTTLMNA | |
| SCHEMBL2940697 | 0.72 | PDPK1 (0.67) | CDK1CDK2PDPK1HTTLMNA | |
| SCHEMBL284830 | 0.72 | PDPK1 (1.00) | CDK1CDK2PDPK1HTTLMNA | |
| SCHEMBL9202451 | 0.71 | HTT (1.00) | HTTLMNAPAK1PKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2129126-A | — | — | None | — | — | JP | disclosed |
| US-5574149-A | Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5-chlorouridine | GLAXO WELLCOME INC. (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0670328-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-09-06 | — | — | EP | disclosed |
| EP-0669341-A1 | Therapeutic Nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-30 | — | — | EP | disclosed |
| EP-0286425-B1 | Therapeutic nucleosides | WELLCOME FOUND (GB) | 1995-01-11 | — | — | EP | disclosed |
| US-5185437-A | 6-substituted 2',3'-dideoxypurine nucleosides; treatment for human immunodeficiency virus and heptatis b virus | BURROUGHS WELLCOME CO. (US) | 1993-02-09 | — | — | US | disclosed |
| US-5068320-A | 2-amino-6-(cyclopropylamino)purine-9-β-D-2',3'-dideoxyribofuranoside and its pharmaceutically acceptable salts | BURROUGHS WELLCOME CO. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0421819-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-04-10 | — | — | EP | disclosed |
| JP-H02129126-A | NUCLEOSIDE FOR CURING | WELLCOME FOUND LTD:THE | 1990-05-17 | — | — | JP | disclosed |
| EP-0366287-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-05-02 | — | — | EP | disclosed |
| EP-0317128-A2 | Anti-HIV Pyrimidine Nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-05-24 | — | — | EP | disclosed |
| EP-0286425-A2 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-10-12 | — | — | EP | disclosed |