Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.86 |
| ▸ | CDK1 | P06493 | 12/20 | 0.86 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 3/20 | 0.54 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268103 | 0.92 | CDK2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL3388864 | 0.76 | PDPK1 (0.68) | CDK2CDK1PDPK1MAP3K5CDC7 | |
| SCHEMBL8939264 | 0.74 | CDK1 (0.62) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL8826284 | 0.74 | CDK2 (0.51) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL9094494 | 0.73 | PDPK1 (0.64) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL7830573 | 0.73 | CDK1 (0.56) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL9204254 | 0.73 | CDK1 (0.65) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6270509 | 0.72 | CDK2 (0.61) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL9197744 | 0.72 | PDPK1 (0.62) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6266042 | 0.72 | CDK2 (1.00) | CDK2CDK1CCNB1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2129126-A | — | — | None | — | — | JP | disclosed |
| EP-0286425-B1 | Therapeutic nucleosides | WELLCOME FOUND (GB) | 1995-01-11 | — | — | EP | disclosed |
| US-5185437-A | 6-substituted 2',3'-dideoxypurine nucleosides; treatment for human immunodeficiency virus and heptatis b virus | BURROUGHS WELLCOME CO. (US) | 1993-02-09 | — | — | US | disclosed |
| US-5068320-A | 2-amino-6-(cyclopropylamino)purine-9-β-D-2',3'-dideoxyribofuranoside and its pharmaceutically acceptable salts | BURROUGHS WELLCOME CO. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0421819-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-04-10 | — | — | EP | disclosed |
| JP-H02129126-A | NUCLEOSIDE FOR CURING | WELLCOME FOUND LTD:THE | 1990-05-17 | — | — | JP | disclosed |
| EP-0366287-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-05-02 | — | — | EP | disclosed |
| EP-0286425-A2 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-10-12 | — | — | EP | disclosed |