Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.50 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1207956 | 0.85 | MAPT (0.56) | MAPTKMT2APKMGAAHPGD | |
| SCHEMBL8706583 | 0.81 | HSD17B10 (0.71) | MAPTKMT2APKMGAAHPGD | |
| SCHEMBL27668680 | 0.81 | KDM4E (0.54) | MAPTKMT2AGAAHPGDALDH1A1 | |
| SCHEMBL8701481 | 0.80 | KMT2A (0.62) | MAPTKMT2APKMGAAALDH1A1 | |
| SCHEMBL13292702 | 0.79 | MAPT (0.67) | MAPTKMT2APKMGAAHPGD | |
| SCHEMBL69530 | 0.79 | MAPT (0.60) | MAPTKMT2AALDH1A1KDM4EALOX5 | |
| SCHEMBL8705860 | 0.79 | MAPT (0.63) | MAPTKMT2APKMGAAHPGD | |
| SCHEMBL8824663 | 0.79 | MAPT (0.63) | MAPTKMT2APKMGAAHPGD | |
| SCHEMBL17674263 | 0.79 | ALOX5 (0.58) | MAPTKMT2AGAAHPGDALDH1A1 | |
| SCHEMBL542043 | 0.78 | KMT2A (0.84) | MAPTKMT2APKMGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512586-A | FOR INHIBITING METABOLISM OF COLLAGEN; IMMUNOSUPPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-30 | — | — | US | disclosed |
| US-5037839-A | Hydroxylase enzyme inhibitors, influencing the metabolism of collagen and biosynthesis of c1q | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |
| US-4968670-A | Pyridine-2,4- and 2,5-dicarboxylic acid derivatives, a process for their preparation, the use thereof, and medicaments based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |