Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939601 | 0.84 | CA12 (0.50) | RECQLCA12CA9KMT2AMEN1 | |
| SCHEMBL8939618 | 0.76 | ALDH1A1 (0.44) | KMT2AMEN1TSHRCYP1A2CYP3A4 | |
| SCHEMBL7111715 | 0.76 | CA12 (0.67) | RECQLCA12CA9KMT2AMEN1 | |
| SCHEMBL8939599 | 0.75 | ALDH1A1 (0.45) | KMT2ATDP1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5191929 | 0.74 | CA12 (0.58) | RECQLCA12CA9KMT2AMEN1 | |
| SCHEMBL27688326 | 0.74 | CA12 (0.59) | RECQLCA12CA9KMT2AMEN1 | |
| SCHEMBL9154917 | 0.74 | ALDH1A1 (0.59) | RECQLCA12CA9KMT2AMEN1 | |
| SCHEMBL9293546 | 0.74 | ALDH1A1 (0.59) | RECQLCA12CA9KMT2AMEN1 | |
| SCHEMBL10906482 | 0.74 | ALDH1A1 (0.59) | RECQLCA12CA9KMT2AMEN1 | |
| SCHEMBL11351755 | 0.74 | GAA (0.53) | KMT2ATSHRCYP1A2TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |