Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939616 | 0.84 | RECQL (0.55) | CA12CA9RECQLTSHRCYP3A4 | |
| SCHEMBL8939597 | 0.78 | LMNA (0.46) | TSHRCYP3A4MEN1KMT2ATP53 | |
| SCHEMBL8939673 | 0.75 | LMNA (0.50) | TSHRCYP3A4MEN1KMT2ATP53 | |
| SCHEMBL8939658 | 0.73 | ALDH1A1 (0.44) | TSHRCYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL8939608 | 0.73 | ALDH1A1 (0.44) | TSHRCYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL8939637 | 0.73 | ALDH1A1 (0.44) | TSHRCYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL9019620 | 0.72 | KDM4E (0.40) | TSHRCYP3A4MEN1KMT2ATDP1 | |
| SCHEMBL8939684 | 0.72 | LMNA (0.47) | TSHRMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL28318605 | 0.71 | RECQL (0.70) | CA12CA9RECQLTSHRCYP3A4 | |
| SCHEMBL9223966 | 0.70 | LMNA (0.44) | TSHRCYP3A4MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |