Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687989 | 1.00 | SIGMAR1 (0.56) | SIGMAR1MAOAMAOBMAPTRXFP1 | |
| SCHEMBL919897 | 0.98 | MAOA (0.56) | SIGMAR1MAOAMAOBMAPTRXFP1 | |
| SCHEMBL668551 | 0.93 | HTR2A (0.54) | SIGMAR1MAOAMAOBL3MBTL1 | |
| SCHEMBL11690401 | 0.90 | SIGMAR1 (0.41) | SIGMAR1MAOAMAOBMAPTRXFP1 | |
| SCHEMBL158694 | 0.87 | MAOA (0.50) | SIGMAR1MAOAMAOB | |
| SCHEMBL11803736 | 0.87 | MAOA (0.40) | SIGMAR1MAOAMAOBL3MBTL1 | |
| SCHEMBL9863991 | 0.85 | MAOB (0.54) | MAOAMAOB | |
| SCHEMBL27498097 | 0.85 | MAOA (0.48) | SIGMAR1MAOAMAOB | |
| SCHEMBL6546948 | 0.84 | SIGMAR1 (0.71) | SIGMAR1MAOAMAOBMAPTRXFP1 | |
| SCHEMBL8085946 | 0.84 | SIGMAR1 (0.71) | SIGMAR1MAOAMAOBMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |