Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18074104 | 0.92 | KDM4E (0.63) | ALDH1A1KDM4EHRH3KCNH2GPR119 | |
| SCHEMBL16665723 | 0.87 | ALDH1A1 (0.69) | ALDH1A1KDM4EKCNH2GPR119OPRM1 | |
| Hydrochloric Acid SCHEMBL16654841 | 0.86 | ALDH1A1 (0.68) | ALDH1A1KDM4EKCNH2GPR119OPRM1 | |
| SCHEMBL28621587 | 0.85 | HRH3 (0.55) | ALDH1A1KDM4EHRH3ACHEGAA | |
| SCHEMBL15156423 | 0.83 | KDM4E (1.00) | ALDH1A1KDM4EHRH3GAAL3MBTL1 | |
| SCHEMBL6576265 | 0.82 | CCR5 (0.64) | ALDH1A1KDM4EOPRM1ACHEKMT2A | |
| SCHEMBL16587845 | 0.82 | ALDH1A1 (0.75) | ALDH1A1KDM4EOPRM1GAAKMT2A | |
| SCHEMBL4040330 | 0.82 | KDM4E (0.75) | ALDH1A1KDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL16653994 | 0.82 | KDM4E (0.62) | ALDH1A1KDM4EKCNH2GPR119OPRM1 | |
| SCHEMBL16665754 | 0.82 | KDM4E (0.62) | ALDH1A1KDM4EKCNH2GPR119OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739891-A2 | Substituted heterocycles | ZENECA LIMITED (GB) | 1996-10-30 | — | — | EP | disclosed |
| EP-0726893-A1 | NOVEL 4-PIPERIDINYL SUBSTITUTED LACTAMES AS NEUROKININ 2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ASTHMA | ZENECA LIMITED (GB) | 1996-08-21 | — | — | EP | disclosed |
| US-5534525-A | Lactam derivatives | ZENECA LIMITED (GB) | 1996-07-09 | — | — | US | disclosed |