Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27360724 | 0.85 | CCR5 (0.53) | CCR5KDM4EALDH1A1DRD2CHRM4 | |
| SCHEMBL14003470 | 0.83 | DRD2 (0.80) | CCR5MCHR1DRD2 | |
| SCHEMBL27360726 | 0.83 | PKM (0.55) | CCR5MCHR1DRD2CHRM4ACHE | |
| SCHEMBL7802383 | 0.82 | HDAC3 (0.56) | CCR5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8940292 | 0.82 | ALDH1A1 (0.71) | KDM4EALDH1A1MEN1KMT2AOPRM1 | |
| SCHEMBL11690275 | 0.81 | ALDH1A1 (0.59) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL16665723 | 0.81 | ALDH1A1 (0.69) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12966205 | 0.80 | KDM1A (0.74) | DRD2 | |
| Hydrochloric Acid SCHEMBL16654841 | 0.80 | ALDH1A1 (0.68) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12813742 | 0.80 | KDM1A (0.74) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409458-A1 | METHOD FOR PREPARING 4-AMINO-4-PHENYLPIPERIDINES | Sanofi-Aventis (FR) | 2004-04-21 | — | — | EP | disclosed |
| EP-1409457-A1 | METHOD FOR PREPARING 4-METHYLAMINO-4-PHENYLPIPERIDINE | Sanofi-Aventis (FR) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003008382-A1 | METHOD FOR PREPARING 4-AMINO-4-PHENYLPIPERIDINES | SANOFI-SYNTHELABO (FR) | 2003-01-30 | — | — | WO | disclosed |
| WO-2003008381-A1 | METHOD FOR PREPARING 4-METHYLAMINO-4-PHENYLPIPERIDINE | SANOFI-SYNTHELABO (FR) | 2003-01-30 | — | — | WO | disclosed |
| EP-1119552-A1 | UREIDOPIPERIDINE DERIVATIVES AS SELECTIVE HUMAN NK 3? RECEPTOR ANTAGONISTS | SANOFI-SYNTHELABO (FR) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021931-A1 | UREIDOPIPERIDINE DERIVATIVES AS SELECTIVE HUMAN NK3 RECEPTOR ANTAGONISTS | SANOFI-SYNTHELABO (FR) | 2000-04-20 | — | — | WO | disclosed |
| EP-0807111-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI (FR) | 1997-11-19 | — | — | EP | disclosed |