Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20691248 | 0.89 | ERN1 (0.45) | ERN1NFE2L2LRRK2SLC9A1JAK2 | |
| SCHEMBL10304909 | 0.89 | S1PR1 (0.46) | ERN1NFE2L2LRRK2SLC9A1JAK2 | |
| SCHEMBL15624568 | 0.88 | SLC9A1 (0.48) | ERN1NFE2L2LRRK2SLC9A1JAK2 | |
| SCHEMBL21408274 | 0.85 | ERN1 (0.45) | ERN1NFE2L2LRRK2SLC9A1CCNT1 | |
| SCHEMBL15455603 | 0.85 | ERN1 (0.45) | ERN1NFE2L2LRRK2SLC9A1JAK2 | |
| SCHEMBL6608193 | 0.83 | SYK (0.52) | ERN1JAK2JAK3KDM4ENR3C1 | |
| SCHEMBL18177606 | 0.83 | ERN1 (0.62) | ERN1NFE2L2SLC9A1KDM4ENR3C1 | |
| SCHEMBL3347567 | 0.83 | HTR7 (0.47) | JAK2JAK3NR3C1NR3C2HTR7 | |
| SCHEMBL4620558 | 0.83 | JAK2 (0.52) | ERN1JAK2JAK3KDM4ENR3C1 | |
| SCHEMBL166380 | 0.82 | NFE2L2 (0.61) | NFE2L2KDM4ENR3C1PTGS1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700384-A1 | PROCESS FOR PREPARING AND RESOLVING 2-PHENYL-3-AMINOPIPERIDINE | PFIZER (US) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027966-A1 | PROCESS FOR PREPARING AND RESOLVING 2-PHENYL-3-AMINOPIPERIDINE | PFIZER INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| EP-0581777-A1 | STEREOSELECTIVE PREPARATION OF SUBSTITUTED PIPERIDINES | PFIZER INC. (US) | 1994-02-09 | — | — | EP | disclosed |
| WO-1992017449-A1 | STEREOSELECTIVE PREPARATION OF SUBSTITUTED PIPERIDINES | PFIZER INC. (US) | 1992-10-15 | — | — | WO | disclosed |