Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.47 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15341172 | 0.86 | HSD11B1 (0.70) | HSD11B1ALDH1A1KMT2AMEN1RECQL | |
| SCHEMBL7274595 | 0.82 | PPARG (0.50) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL7695463 | 0.80 | PPARG (0.52) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL9852204 | 0.79 | MEN1 (0.60) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL18179825 | 0.79 | MEN1 (0.60) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL4126086 | 0.79 | MEN1 (0.60) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| Iodide SCHEMBL22068772 | 0.78 | CA2 (0.59) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| Alcohol SCHEMBL8831116 | 0.76 | KMT2A (0.62) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL581359 | 0.75 | KMT2A (0.65) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL15952072 | 0.75 | GAA (0.63) | PPARGALDH1A1ENPP1ENPP2ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565470-A | HYPOTENSIVE OR ANTIARRHYTHMIA AGENTS, ALSO FOR TREATMENT OF ANGINA OR GLAUCOMA | SANOFI (FR) | 1996-10-15 | — | — | US | disclosed |
| US-5340820-A | Useful for treatment of ocular diseases, angina pectoris, hypertension and arrhythmia | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |