Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129859 | 0.87 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1RECQLMAPT | |
| SCHEMBL8940816 | 0.82 | HSD11B1 (0.54) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL8940865 | 0.80 | PPARG (0.49) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL7273970 | 0.79 | HTT (0.55) | ALDH1A1KMT2AMEN1HTTPOLB | |
| SCHEMBL7695463 | 0.79 | PPARG (0.52) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL4126086 | 0.78 | MEN1 (0.60) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL18179825 | 0.78 | MEN1 (0.60) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL9852204 | 0.78 | MEN1 (0.60) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| SCHEMBL1827851 | 0.77 | CNR1 (0.53) | PPARGALDH1A1ENPP1ENPP2ENPP3 | |
| Iodide SCHEMBL22068772 | 0.77 | CA2 (0.59) | PPARGALDH1A1ENPP1ENPP2ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565470-A | HYPOTENSIVE OR ANTIARRHYTHMIA AGENTS, ALSO FOR TREATMENT OF ANGINA OR GLAUCOMA | SANOFI (FR) | 1996-10-15 | — | — | US | disclosed |
| EP-0302792-B1 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI SA (FR) | 1994-10-26 | — | — | EP | disclosed |
| US-5340820-A | Useful for treatment of ocular diseases, angina pectoris, hypertension and arrhythmia | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0302793-B1 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | disclosed |
| US-5215988-A | Treating angina, hypertension, arrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-06-01 | — | — | US | disclosed |
| US-5182291-A | Angina pectoris, hypotensive, antiarrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5039700-A | Cardiovascular disorders, antitumor agents | SANOFI (FR) | 1991-08-13 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4994474-A | Hypotensive agents | SANOFI (FR) | 1991-02-19 | — | — | US | disclosed |
| US-4957925-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA | SANOFI (FR) | 1990-09-18 | — | — | US | disclosed |
| EP-0302792-A2 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302793-A2 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | ELF SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |