Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190863 | 0.84 | — | — | |
| Bromide SCHEMBL122634 | 0.77 | ALDH1A1 (0.43) | — | |
| SCHEMBL6935663 | 0.75 | KAT2B (0.36) | — | |
| Bromide SCHEMBL3844643 | 0.73 | DPP7 (0.33) | — | |
| Hydrochloric Acid SCHEMBL4019649 | 0.73 | ALDH1A1 (0.43) | — | |
| SCHEMBL284817 | 0.72 | PTGS1 (0.42) | — | |
| SCHEMBL2001403 | 0.70 | — | — | |
| Bromide SCHEMBL31453019 | 0.70 | CYP2D6 (0.33) | — | |
| SCHEMBL7074124 | 0.69 | NPC1 (0.43) | — | |
| SCHEMBL1652278 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580904-A | PENETRATE BLOOD-BRAIN BARRIER | DRUG DELIVERY SYSTEM INSTITUTE, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0614886-B1 | COMPOUND CAPABLE OF INTRACEREBRAL RESIDENCE AND USE THEREOF | DRUG DELIVERY SYSTEM INST LTD (JP) | 1996-10-16 | — | — | EP | disclosed |
| EP-0614886-A1 | COMPOUND CAPABLE OF INTRACEREBRAL RESIDENCE AND USE THEREOF | DRUG DELIVERY SYSTEM INSTITUTE, LTD. (JP) | 1994-09-14 | — | — | EP | disclosed |