Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.33 |
| ▸ | FDPS | P14324 | 3/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14989365 | 0.79 | SPHK1 (0.41) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL9374804 | 0.79 | SPHK1 (0.41) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL9363153 | 0.79 | SPHK1 (0.41) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL9379337 | 0.79 | SPHK1 (0.41) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL3888311 | 0.79 | SPHK1 (0.41) | LMNADNM1TSHRTHRBOPRM1 | |
| SCHEMBL23806431 | 0.78 | OPRM1 (0.39) | LMNADNM1TSHROPRM1SPHK1 | |
| SCHEMBL28567418 | 0.77 | HMGCR (0.37) | LMNAHMGCR | |
| SCHEMBL31230828 | 0.77 | TSHR (0.36) | LMNADNM1TSHROPRM1HMGCR | |
| SCHEMBL7122689 | 0.76 | DNM1 (0.42) | DNM1TSHRTHRBHMGCR | |
| SCHEMBL25756980 | 0.75 | OPRM1 (0.37) | LMNADNM1TSHROPRM1SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996019444-A1 | SULFONATE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |
| WO-1996019446-A1 | β-CARBOXY SULFONAMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |
| US-5510379-A | USEFUL FOR TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-04-23 | — | — | US | disclosed |
| US-5491170-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-02-13 | — | — | US | disclosed |