Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28589830 | 0.67 | PLA2G7 (0.48) | PLA2G7HSD11B1KMT2APOLBRAB9A | |
| SCHEMBL27781528 | 0.66 | PLA2G7 (0.52) | PLA2G7HSD11B1GRM2KMT2APOLB | |
| SCHEMBL27781527 | 0.66 | PLA2G7 (0.52) | PLA2G7HSD11B1GRM2KMT2APOLB | |
| SCHEMBL29294775 | 0.64 | PLA2G7 (0.64) | PLA2G7HSD11B1KMT2APOLBRAB9A | |
| SCHEMBL277914 | 0.62 | PLA2G7 (0.67) | PLA2G7HSD11B1GRM2KMT2APOLB | |
| SCHEMBL321560 | 0.62 | PLA2G7 (0.61) | PLA2G7HSD11B1KMT2APOLBRAB9A | |
| SCHEMBL1979999 | 0.62 | PLA2G7 (0.43) | PLA2G7HSD11B1GRM2KMT2APOLB | |
| SCHEMBL1980000 | 0.62 | PLA2G7 (0.51) | PLA2G7HSD11B1KMT2APOLBRAB9A | |
| SCHEMBL10436633 | 0.62 | MAPK14 (0.45) | PLA2G7HSD11B1GRM2KMT2APOLB | |
| SCHEMBL13176930 | 0.61 | PLA2G7 (0.50) | PLA2G7HSD11B1GRM2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995032953-A1 | AMIDE TETRAZOLE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1995-12-07 | — | — | WO | claimed |
| WO-1996019446-A1 | β-CARBOXY SULFONAMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |
| WO-1996019444-A1 | SULFONATE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |
| US-5510379-A | USEFUL FOR TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-04-23 | — | — | US | disclosed |
| US-5491170-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-02-13 | — | — | US | disclosed |
| WO-1995032953-A1 | AMIDE TETRAZOLE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1995-12-07 | — | — | WO | disclosed |
| US-5461049-A | Treating hypercholesterolemia, atherosclerosis | WARNER-LAMBERT COMPANY (US) | 1995-10-24 | — | — | US | disclosed |