Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9155272 | 0.91 | CRHBP (0.48) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL11426966 | 0.86 | CRHBP (0.42) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL11428861 | 0.86 | CRHBP (0.45) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL11419734 | 0.85 | CRHBP (0.47) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL11431643 | 0.85 | CRHBP (0.44) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL9636461 | 0.84 | CRHBP (0.43) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL3975558 | 0.83 | CRHBP (0.47) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL11417208 | 0.82 | CRHBP (0.43) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL10886763 | 0.82 | CRHBP (0.43) | CRHBPCRHR2DRD2DRD4TSHR | |
| SCHEMBL11431614 | 0.82 | CRHBP (0.43) | CRHBPCRHR2DRD2DRD4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | claimed |
| US-4828741-A | N-substituted tetrahydroquinolines for use as antioxidants in lubricants | CIBA-GEIGY CORPORATION (US) | 1989-05-09 | — | — | US | claimed |
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | disclosed |
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | disclosed |
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | disclosed |
| US-5578711-A | Process for the preparation of dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1996-11-26 | — | — | US | disclosed |
| US-5541299-A | Process for the preparation of dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1996-07-30 | — | — | US | disclosed |
| US-5502171-A | Process for the preparation of dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| EP-0446731-B1 | Process for the manufacture of azo dyes | BAYER AG (DE) | 1995-05-03 | — | — | EP | disclosed |
| EP-0273868-B1 | N-SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIOXIDANTS FOR LUBRICANTS | CIBA-GEIGY AG (CH) | 1992-07-08 | — | — | EP | disclosed |
| US-5097034-A | Use in thermoreactive papers and pressure-sensitive recording materials | BAYER AKTIENGESELLSCHAFT (DE) | 1992-03-17 | — | — | US | disclosed |
| US-4255326-A | MONOAZO DYES; THIOPHENE DYES; POLYAMIDES, CELLULOSE ACETATE AND WOOL | EASTMAN KODAK COMPANY (US) | 1981-03-10 | — | — | US | disclosed |
| EP-0017558-A1 | Heterocyclic azo compounds having sulfate groups | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1980-10-15 | — | — | EP | disclosed |
| US-4185151-A | 1-R-2-(U-HYDROXYALKYL-2,2,4-TRIMETHYL TETRAHYDROQUINOL-6-YL) BENZ(CD)INDOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-01-22 | — | — | US | disclosed |
| US-4180663-A | FORMYLATION OF AROMATIC AMINE, CONDENSATION WITH MALONONITRILE GENERATED IN SITU FROM CYANOACETAMIDE | EASTMAN KODAK COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4161601-A | YELLOW POLYESTERS | EASTMAN KODAK COMPANY (US) | 1979-07-17 | — | — | US | disclosed |
| US-4052379-A | DYES FROM TRIFLUOROMETHYL-2-AMINOBENZOTHIAZOLE DIAZO COMPONENTS | EASTMAN KODAK COMPANY (US) | 1977-10-04 | — | — | US | disclosed |
| US-4006127-A | Cationic diazacyanine dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
| US-4000141-A | SUBSTITUTED TETRAHYDRO QUINOLINE CATIONIC DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-12-28 | — | — | US | disclosed |
| US-3991042-A | Basic azo dyestuffs containing a benzthiazole and a tetrahydroquinoline nucleus | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-09 | — | — | US | disclosed |