Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11432748 | 0.88 | CRHBP (0.45) | CRHBPCRHR2TSHRDRD2DRD4 | |
| SCHEMBL9637831 | 0.80 | CRHBP (0.45) | CRHBPCRHR2TSHRDRD2DRD4 | |
| SCHEMBL11588357 | 0.80 | DRD2 (0.46) | CRHBPCRHR2DRD2DRD4MAPT | |
| SCHEMBL14372114 | 0.79 | CRHBP (0.49) | CRHBPCRHR2TSHRDRD2DRD4 | |
| SCHEMBL10887272 | 0.79 | CRHBP (0.39) | CRHBPCRHR2TSHRDRD2DRD4 | |
| SCHEMBL9637792 | 0.79 | CRHBP (0.48) | CRHBPCRHR2TSHRDRD2DRD4 | |
| SCHEMBL18826080 | 0.78 | TSHR (0.41) | CRHBPCRHR2TSHRDRD2DRD4 | |
| Hydrochloric Acid SCHEMBL10975696 | 0.77 | MAPT (0.34) | CRHBPCRHR2MAPTALDH1A1GAA | |
| SCHEMBL11416787 | 0.76 | CRHBP (0.44) | CRHBPCRHR2TSHRDRD2DRD4 | |
| SCHEMBL24619642 | 0.76 | CRHBP (0.61) | CRHBPCRHR2TSHRDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | claimed |
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | disclosed |
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | disclosed |
| CN-111004177-A | Preparation method of 1-hydroxyethyl-2, 2, 4-trimethyl-1, 2,3, 4-tetrahydroquinoline | 河南省科学院高新技术研究中心 | 2020-04-14 | — | — | CN | disclosed |
| US-5578711-A | Process for the preparation of dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1996-11-26 | — | — | US | disclosed |
| US-5541299-A | Process for the preparation of dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1996-07-30 | — | — | US | disclosed |
| US-5502171-A | Process for the preparation of dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5097034-A | Use in thermoreactive papers and pressure-sensitive recording materials | BAYER AKTIENGESELLSCHAFT (DE) | 1992-03-17 | — | — | US | disclosed |
| EP-0037491-B1 | DIMETHINIC DYESTUFFS, THEIR PREPARATION AND THEIR USE IN DYEING SYNTHETIC AND NATURAL MATERIALS | BAYER AG (DE) | 1984-02-08 | — | — | EP | disclosed |
| US-4366314-A | STYRYL DYE | BAYER AKTIENGESELLSCHAFT (DE) | 1982-12-28 | — | — | US | disclosed |