SCHEMBL9637792

SCHEMBL9637792

CC1CC(C)(C)N(C)c2ccccc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.48
CRHR2 Q13324 1/20 0.48
TSHR P16473 1/20 0.44
DRD2 P14416 1/20 0.42
DRD4 P21917 1/20 0.42
ALDH1A1 P00352 4/20 0.42
MAPT P10636 4/20 0.42
NOTUM Q6P988 1/20 0.42
GPR3 P46089 1/20 0.39
GAA P10253 3/20 0.38
LMNA P02545 2/20 0.38
PAX8 Q06710 1/20 0.38
MCL1 Q07820 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NPSR1 Q6W5P4 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KMT2A Q03164 1/20 0.37
CHRNA7 P36544 1/20 0.36
ROCK1 Q13464 1/20 0.36
HTR1A P08908 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9155272 0.84 CRHBP (0.48) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL14372114 0.81 CRHBP (0.49) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL27989560 0.81 CRHBP (0.49) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL11432748 0.80 CRHBP (0.45) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL11428861 0.80 CRHBP (0.45) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL9013201 0.79 DRD2 (0.46) CRHBPCRHR2DRD2DRD4ALDH1A1
SCHEMBL8942352 0.79 CRHBP (0.47) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL11424524 0.79 CRHBP (0.44) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL3975558 0.79 CRHBP (0.47) CRHBPCRHR2TSHRDRD2DRD4
SCHEMBL11431643 0.79 CRHBP (0.44) CRHBPCRHR2TSHRDRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4965006-A N-substituted tetrahydroquinolines for use as antioxidants in lubricants CIBA-GEIGY CORPORATION (US) 1990-10-23 US claimed
CN-100384944-C Tetrahydro quinoline functional dye containing thiophene bridge chain UNIV DALIAN SCIENCE & ENG (CN) 2008-04-30 CN disclosed
CN-1858117-A Tetrahydro quinoline functional dye containing thiophene bridge chain UNIV DALIAN SCIENCE & ENG (CN) 2006-11-08 CN disclosed
EP-0273868-B1 N-SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIOXIDANTS FOR LUBRICANTS CIBA-GEIGY AG (CH) 1992-07-08 EP disclosed
EP-0237915-B1 CHROMOGENIC PHTHALIDES, THEIR PREPARATION AND USE BAYER AG (DE) 1992-05-13 EP disclosed
US-5091517-A Suitable for dyeing and printing of textiles made of polyester and polyamide fibers CIBA-GEIGY CORPORATION (US) 1992-02-25 US disclosed
US-4965006-A N-substituted tetrahydroquinolines for use as antioxidants in lubricants CIBA-GEIGY CORPORATION (US) 1990-10-23 US disclosed
EP-0210139-B1 CATIONIC AZO-1,2,3-THIADIAZOLE COMPOUNDS CIBA-GEIGY AG (CH) 1990-09-19 EP disclosed
US-4929732-A N-substituted tetrahydroquinolines for use as antioxidants in lubricants CIBA-GEIGY CORPORATION (US) 1990-05-29 US disclosed
US-4919832-A HYDRAULIC OIL OR METAL WORKING FLUID CIBA-GEIGY CORPORATION (US) 1990-04-24 US disclosed
EP-0237915-A2 Chromogenic phthalides, their preparation and use BAYER AG (DE) 1987-09-23 EP disclosed
EP-0210139-A2 Cationic azo-1,2,3-thiadiazole compounds CIBA-GEIGY AG (CH) 1987-01-28 EP disclosed
US-4500715-A CHEMICAL INTERMEDIATES FOR PLANT SAFENING AGENTS AND DYES BAYER AKTIENGESELLSCHAFT (DE) 1985-02-19 US disclosed
EP-0022521-B1 PREPARATION OF CATIONIC TRIARYL METHANE DYESTUFFS BAYER AG (DE) 1982-09-15 EP disclosed
US-4330476-A CONDENSATION OF AROMATIC ALDEHYDE WITH AROMATIC AMINE FOLLOWED BY OXIDATION BAYER AKTIENGESELLSCHAFT (DE) 1982-05-18 US disclosed
US-4268438-A Cationic 1,3,4-thiadiazole dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1981-05-19 US disclosed
EP-0022521-A1 Preparation of cationic triaryl methane dyestuffs BAYER AG (DE) 1981-01-21 EP disclosed
US-4185151-A 1-R-2-(U-HYDROXYALKYL-2,2,4-TRIMETHYL TETRAHYDROQUINOL-6-YL) BENZ(CD)INDOLES BAYER AKTIENGESELLSCHAFT (DE) 1980-01-22 US disclosed
US-4000141-A SUBSTITUTED TETRAHYDRO QUINOLINE CATIONIC DYESTUFFS BAYER AKTIENGESELLSCHAFT (DT) 1976-12-28 US disclosed
US-3991042-A Basic azo dyestuffs containing a benzthiazole and a tetrahydroquinoline nucleus BAYER AKTIENGESELLSCHAFT (DT) 1976-11-09 US disclosed