Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942328 | 0.88 | PTK2 (0.34) | DPP4DPP8DPP9 | |
| SCHEMBL8351315 | 0.85 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDDPP4DPP8 | |
| SCHEMBL8607750 | 0.81 | GAA (0.52) | KDM4EDPP4DPP8DPP9GAA | |
| SCHEMBL8942229 | 0.79 | KDM4E (0.53) | ALDH1A1KDM4EHPGDGAAGABRA2 | |
| SCHEMBL8942506 | 0.78 | KDM4E (0.49) | ALDH1A1KDM4EHPGDDPP4DPP8 | |
| SCHEMBL8942203 | 0.77 | DPP4 (0.43) | ALDH1A1KDM4EHPGDDPP4DPP8 | |
| SCHEMBL8350370 | 0.73 | DPP4 (0.31) | DPP4DPP8DPP9 | |
| SCHEMBL8608472 | 0.72 | GAA (0.46) | KDM4EDPP4DPP8DPP9GAA | |
| SCHEMBL8349215 | 0.71 | SIRT6 (0.33) | LMNA | |
| SCHEMBL8942235 | 0.70 | KDM4E (0.51) | ALDH1A1KDM4EHPGDDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | claimed |
| US-5482933-A | ANOXIA, ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5480876-A | FROM ANOXIA OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |