Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.54 |
| ▸ | FEN1 | P39748 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782975 | 0.82 | HDAC8 (0.69) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL2830822 | 0.82 | HDAC8 (0.73) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL31295303 | 0.82 | HDAC8 (0.73) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL9187790 | 0.81 | HDAC8 (0.67) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL11668725 | 0.81 | HDAC8 (0.67) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL8782857 | 0.80 | HDAC8 (0.57) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL5246552 | 0.79 | HPGD (0.72) | HDAC8NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL14336245 | 0.78 | ALDH1A1 (0.64) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL28412237 | 0.78 | HDAC8 (0.63) | HDAC8AKR1C3NPC1ERCC5FEN1 | |
| SCHEMBL8783294 | 0.78 | MEN1 (0.57) | HDAC8AKR1C3NPC1ERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |