Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783294 | 0.87 | MEN1 (0.57) | HDAC8ALOX5AKR1C3NPC1RAB9A | |
| SCHEMBL8783008 | 0.84 | LMNA (0.53) | HDAC8ALOX5AKR1C3NPC1RAB9A | |
| SCHEMBL8783449 | 0.80 | ALOX5 (0.57) | HDAC8ALOX5AKR1C3NPC1RAB9A | |
| SCHEMBL8942816 | 0.80 | HDAC8 (0.61) | HDAC8AKR1C3NPC1RAB9AERCC5 | |
| SCHEMBL8782837 | 0.79 | ALDH1A1 (0.65) | HDAC8ALOX5AKR1C3NPC1RAB9A | |
| SCHEMBL8782847 | 0.79 | ALDH1A1 (0.65) | HDAC8ALOX5AKR1C3NPC1RAB9A | |
| SCHEMBL8782975 | 0.79 | HDAC8 (0.69) | HDAC8AKR1C3NPC1RAB9AERCC5 | |
| SCHEMBL2830822 | 0.78 | HDAC8 (0.73) | HDAC8AKR1C3NPC1RAB9AERCC5 | |
| SCHEMBL31295303 | 0.78 | HDAC8 (0.73) | HDAC8AKR1C3NPC1RAB9AERCC5 | |
| SCHEMBL8782586 | 0.78 | SNCA (0.49) | HDAC8ALOX5NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |