Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943030 | 1.00 | ALOX12 (0.49) | ALOX12TSHRHPGDPOLBGAA | |
| SCHEMBL21173608 | 0.83 | HPGD (0.57) | ALOX12TSHRHPGDPOLBGAA | |
| SCHEMBL11203822 | 0.83 | ALOX12 (0.42) | ALOX12HPGDPOLBGAAKDM4E | |
| SCHEMBL28000035 | 0.81 | TSHR (0.49) | TSHRHPGDKDM4EMAPTGABRA1 | |
| SCHEMBL23491266 | 0.80 | TSHR (0.52) | TSHRHPGDGABRA1GABRB2FAAH | |
| SCHEMBL310186 | 0.80 | TSHR (0.52) | TSHRHPGDTDP1GABRA1GABRB2 | |
| SCHEMBL6900092 | 0.80 | TSHR (0.52) | TSHRHPGDTDP1GABRA1GABRB2 | |
| SCHEMBL202738 | 0.78 | TSHR (0.68) | TSHRHPGDPOLBGAAUSP2 | |
| SCHEMBL560346 | 0.78 | TSHR (0.68) | TSHRHPGDPOLBGAAUSP2 | |
| SCHEMBL561299 | 0.78 | TSHR (0.68) | TSHRHPGDPOLBGAAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1036710-C | Chemical process | ZENECA LTD (GB) | 1997-12-17 | — | — | CN | disclosed |
| EP-0584988-B1 | Process for the preparation of salicylaldoxine derivatives | ZENECA LTD (GB) | 1996-10-23 | — | — | EP | disclosed |
| US-5502254-A | Method for the preparation of 2-hydroxyarylaldoximes | ZENECA LIMITED (GB) | 1996-03-26 | — | — | US | disclosed |
| US-5399761-A | Method for the preparation of 2-hydroxyarylaldoximes | ZENECA LIMITED (GB) | 1995-03-21 | — | — | US | disclosed |
| CN-1099377-A | Chemical process | ZENECA LTD (GB) | 1995-03-01 | — | — | CN | disclosed |
| EP-0584988-A1 | Process for the preparation of salicylaldoxine derivatives | ZENECA LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |