Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28132698 | 0.78 | MAP2K1 (0.35) | ALDH1A1POLBMAPTMAPK8DYRK1A | |
| SCHEMBL7618944 | 0.72 | — | — | |
| SCHEMBL7616750 | 0.72 | CCR8 (0.31) | — | |
| SCHEMBL14491 | 0.72 | TYMP (0.49) | ALDH1A1POLBMAPT | |
| SCHEMBL7546872 | 0.71 | ALDH1A1 (0.42) | TP53MMP2ALDH1A1POLBMAPT | |
| SCHEMBL422814 | 0.70 | — | — | |
| SCHEMBL1526613 | 0.69 | ELANE (0.37) | ALDH1A1POLBMAPT | |
| SCHEMBL9443405 | 0.69 | CRBN (0.35) | TP53MMP2MAPK8DYRK1ACLK4 | |
| Benzene SCHEMBL26606838 | 0.67 | MAPK8 (0.36) | MAPTMAPK8DYRK1ACLK4DYRK1B | |
| SCHEMBL4253406 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873673-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20160304469-A1 | 2-Thiopyrimidinones | PFIZER INC. (US) | 2016-10-20 | — | — | US | disclosed |
| CN-103917529-B | 2-Thiopyrimidinones | 辉瑞大药厂 | 2016-08-17 | — | — | CN | disclosed |
| US-9399626-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-20140288049-A1 | 2-Thiopyrimidinones | PFIZER (US) | 2014-09-25 | — | — | US | disclosed |
| US-8841314-B2 | 2-Thiopyrimidinones | PFIZER INC. (US) | 2014-09-23 | — | — | US | disclosed |
| EP-2776405-A1 | 2-THIOPYRIMIDINONES | Pfizer Inc (US) | 2014-09-17 | — | — | EP | disclosed |
| US-8835449-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2014-09-16 | — | — | US | disclosed |
| CN-103917529-A | 2-thiopyrimidinones | PFIZER | 2014-07-09 | — | — | CN | disclosed |
| US-20130296351-A1 | 2-Thiopyrimidinones | PFIZER INC. | 2013-11-07 | — | — | US | disclosed |
| US-20130123230-A1 | 2-Thiopyrimidinones | PFIZER INC. | 2013-05-16 | — | — | US | disclosed |
| WO-2013068875-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2013-05-16 | — | — | WO | disclosed |
| US-5547686-A | INCREASING AMOUNTS OF UNSATURATED FATTY ACIDS IN TISSUES AND MILK BY FEEDING MIXTURE CONTAINING UNSATURATED FATTY AMIDE WHICH IS RESISTANT TO HYDROGENATION BY MICROORGANISMS IN RUMEN | CLEMSON UNIVERSITY (US) | 1996-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123230-A1 | 2-Thiopyrimidinones | MPO, SERPINB1, TNNI3 | TP53 3900/4885MMP2 40/4885ALDH1A1 280/4885 |
| US-20160304469-A1 | 2-Thiopyrimidinones | MPO, SERPINB1, TNNI3 | TP53 3900/4885MMP2 40/4885ALDH1A1 280/4885 |
| US-20140288049-A1 | 2-Thiopyrimidinones | MPO, SERPINB1, TNNI3 | TP53 3900/4885MMP2 40/4885ALDH1A1 280/4885 |
| US-20130296351-A1 | 2-Thiopyrimidinones | MPO, SERPINB1, TNNI3 | TP53 3900/4885MMP2 40/4885ALDH1A1 280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.