SCHEMBL8943501

SCHEMBL8943501

CC(C)(C)[Si](C)(C)OC[C@H]1CCC[C@@H]1CO

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 1/20 0.32
PPM1D O15297 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9135419 1.00 FKBP1A (0.32) FKBP1APPM1D
SCHEMBL9135416 1.00 FKBP1A (0.32) FKBP1APPM1D
SCHEMBL8943504 1.00 FKBP1A (0.32) FKBP1APPM1D
SCHEMBL9133269 1.00 FKBP1A (0.32) FKBP1APPM1D
SCHEMBL7296965 0.96 PABPC1 (0.33) FKBP1A
SCHEMBL7291318 0.96 PABPC1 (0.33) FKBP1A
SCHEMBL23669704 0.94
SCHEMBL31644526 0.94
SCHEMBL23670055 0.94
SCHEMBL5057553 0.83 TOP2A (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0614457-B1 LEUKOTRIENE-B 4? DERIVATIVES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS SCHERING AG (DE) 1996-08-21 EP disclosed
US-5502075-A Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents SCHERING AKTIENGESELLSCHAFT (DE) 1996-03-26 US disclosed
EP-0529022-B1 NEW LEUKOTRIENE B 4? DERIVATIVES, METHOD FOR PREPARING THEM AND THEIR USE AS DRUGS SCHERING AG (DE) 1995-09-27 EP disclosed
US-5414016-A New leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents SCHERING AKTIENGESELLSCHAFT (DE) 1995-05-09 US disclosed
WO-1992016504-A1 NEW LEUKOTRIENE B4 DERIVATIVES, METHOD FOR PREPARING THEM AND THEIR USE AS DRUGS SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) 1992-10-01 WO disclosed