SCHEMBL8943573

SCHEMBL8943573

CCOC(=O)C(Sc1nc(OC)cc(OC)n1)C(C)(C)C#N

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.38
HTT P42858 1/20 0.37
ADORA3 P0DMS8 2/20 0.37
ADORA1 P30542 1/20 0.36
KMT2A Q03164 1/20 0.35
POLB P06746 2/20 0.35
MAPT P10636 2/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
NPSR1 Q6W5P4 2/20 0.34
CTSK P43235 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
EDNRB P24530 1/20 0.34
EDNRA P25101 1/20 0.34
PTGES O14684 1/20 0.33
ALOX5 P09917 1/20 0.33
PPARG P37231 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8943379 0.91 EDNRB (0.36) ALDH1A1ADORA3ADORA1EDNRBEDNRA
SCHEMBL8943555 0.86 ALDH1A1 (0.33) ALDH1A1ADORA3
SCHEMBL8943529 0.85 EDNRB (0.37) ALDH1A1KDM4EEDNRBEDNRAPTGES
SCHEMBL8943560 0.85 ALDH1A1 (0.41) ALDH1A1ADORA3ADORA1POLBMAPT
SCHEMBL9148023 0.84 ALDH1A1 (0.32) ALDH1A1PTGESALOX5PPARG
SCHEMBL8943363 0.84 ALDH1A1 (0.40) ALDH1A1ADORA3ADORA1POLBMAPT
SCHEMBL9082340 0.82 ADORA3 (0.40) ALDH1A1ADORA3ADORA1POLBMAPT
SCHEMBL8537289 0.78 LMNA (0.35) ALDH1A1ADORA3KDM4EGAASMN1; SMN2
SCHEMBL9573157 0.77 GAA (0.53) ALDH1A1HTTADORA3ADORA1POLB
SCHEMBL9082509 0.76 ADORA3 (0.41) ALDH1A1ADORA3ADORA1POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0517215-A1 Pyrimidine or triazine derivative, process for preparing the same and herbicide using the same UBE INDUSTRIES, LTD. (JP) 1992-12-09 EP claimed
US-5529977-A A 3-ALKOXYBUTYRYLIMIDAZOLE COMPOUND UBE INDUSTRIES, LTD. (JP) 1996-06-25 US disclosed
US-5387575-A Pyrimidine derivatives, process for preparing the same and herbicide using the same UBE INDUSTRIES, LTD. (JP) 1995-02-07 US disclosed
EP-0517215-A1 Pyrimidine or triazine derivative, process for preparing the same and herbicide using the same UBE INDUSTRIES, LTD. (JP) 1992-12-09 EP disclosed