SCHEMBL8943792

SCHEMBL8943792

COC(=O)CCC[C@@H]1C[C@@H](C(=O)c2ccc(-c3ccc(C#N)cc3)cc2)N(CCCc2ccccc2)C1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 1/20 0.38
OPRM1 P35372 2/20 0.38
HTR1A P08908 1/20 0.38
DRD4 P21917 1/20 0.38
HTR2A P28223 1/20 0.38
HRH1 P35367 1/20 0.38
CHRM4 P08173 1/20 0.38
KCNH2 Q12809 1/20 0.36
ABCB1 P08183 1/20 0.36
HPGD P15428 1/20 0.36
ABCG2 Q9UNQ0 1/20 0.36
KDM4E B2RXH2 5/20 0.36
MAPT P10636 5/20 0.36
TDP1 Q9NUW8 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
NR3C2 P08235 1/20 0.36
KDM1A O60341 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7272654 0.85 ABCB1 (0.42) MCHR1OPRM1HTR1ADRD4HTR2A
SCHEMBL8943799 0.84 HTR1A (0.37) MCHR1OPRM1HTR1ADRD4HTR2A
SCHEMBL7276141 0.82 ABCB1 (0.41) OPRM1HTR1ADRD4HTR2AHRH1
SCHEMBL7274708 0.76 CHRM4 (0.42) MCHR1OPRM1HTR1ADRD4HTR2A
Hydrochloric Acid SCHEMBL7274645 0.76 ITGB3 (0.41) OPRM1MAPTCHRNB2CHRNB4CHRNA3
SCHEMBL7274705 0.76 MCHR1 (0.37) MCHR1OPRM1HTR1ADRD4HTR2A
SCHEMBL7274188 0.76 OGA (0.41) OPRM1LMNAOPRD1
SCHEMBL7282551 0.76 ABCB1 (0.44) MCHR1OPRM1HTR1ADRD4HTR2A
SCHEMBL7281268 0.76 ABCB1 (0.44) MCHR1OPRM1HTR1ADRD4HTR2A
SCHEMBL7274151 0.76 ABCB1 (0.44) MCHR1OPRM1HTR1ADRD4HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5541343-A ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS KARL THOMAE GMBH (DE) 1996-07-30 US disclosed