Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 5/20 | 0.60 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.58 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041589 | 0.87 | KDM4E (0.59) | KDM4EHSD17B10NPSR1MAPTMEN1 | |
| SCHEMBL8395355 | 0.87 | KDM4E (0.53) | KDM4EHSD17B10PPARGAGTR1AGTR2 | |
| SCHEMBL10443835 | 0.86 | NPSR1 (0.65) | KDM4EHSD17B10NPSR1MAPTMEN1 | |
| SCHEMBL8391622 | 0.85 | PPARG (0.69) | KDM4EHSD17B10PPARGAGTR1AGTR2 | |
| SCHEMBL8944521 | 0.85 | PPARG (0.63) | KDM4EHSD17B10PPARGAGTR1AGTR2 | |
| SCHEMBL246445 | 0.84 | MAPT (0.71) | KDM4EHSD17B10NPSR1MAPTMEN1 | |
| SCHEMBL8392673 | 0.82 | PPARG (0.66) | KDM4EHSD17B10PPARGAGTR1AGTR2 | |
| SCHEMBL9043965 | 0.82 | KDM4E (0.52) | KDM4EHSD17B10NPSR1MAPTMEN1 | |
| SCHEMBL8393562 | 0.81 | SMN1; SMN2 (0.73) | KDM4EHSD17B10PPARGAGTR1AGTR2 | |
| SCHEMBL8396864 | 0.81 | PPARG (0.72) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |