Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | PDE6D | O43924 | 1/20 | 0.61 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.61 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.61 |
| ▸ | METAP2 | P50579 | 1/20 | 0.60 |
| ▸ | METAP1 | P53582 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10443835 | 0.92 | NPSR1 (0.65) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL10443834 | 0.89 | MAPT (0.61) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL8944506 | 0.84 | KDM4E (0.62) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL229709 | 0.83 | KDM4E (0.68) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL2610128 | 0.83 | KDM4E (0.67) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL15559304 | 0.82 | MAPK1 (0.58) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL9041589 | 0.81 | KDM4E (0.59) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL9622725 | 0.81 | METAP2 (0.68) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL21085204 | 0.80 | KDM4E (0.64) | MAPTNPSR1KDM4EHSD17B10MAPK1 | |
| SCHEMBL13451647 | 0.80 | KDM4E (0.67) | MAPTNPSR1KDM4EHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584717-B2 | MIF modulators | YALE UNIVERSITY (US) | 2023-02-21 | — | — | US | disclosed |
| US-11584717-B2 | MIF modulators | YALE UNIVERSITY (US) | 2023-02-21 | — | — | US | disclosed |
| US-20200377457-A1 | MIF MODULATORS | UNIV YALE (US) | 2020-12-03 | — | — | US | disclosed |
| US-20200377457-A1 | MIF MODULATORS | UNIV YALE (US) | 2020-12-03 | — | — | US | disclosed |
| US-20190270706-A1 | MIF MODULATORS | UNIV YALE (US) | 2019-09-05 | — | — | US | disclosed |
| US-20190270706-A1 | MIF MODULATORS | UNIV YALE (US) | 2019-09-05 | — | — | US | disclosed |
| US-10202343-B2 | MIF modulators | YALE UNIVERSITY (US) | 2019-02-12 | — | — | US | disclosed |
| US-10202343-B2 | MIF modulators | YALE UNIVERSITY (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180162813-A1 | MIF MODULATORS | YALE UNIVERSITY | 2018-06-14 | — | — | US | disclosed |
| US-20180162813-A1 | MIF MODULATORS | YALE UNIVERSITY | 2018-06-14 | — | — | US | disclosed |
| US-20120040974-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-02-16 | — | — | US | disclosed |
| US-20120004261-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120004261-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120004261-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-01-05 | — | — | US | disclosed |
| WO-2011140202-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2011-11-10 | — | — | WO | disclosed |
| CN-102186833-A | MIF modulators | UNIV YALE | 2011-09-14 | — | — | CN | disclosed |
| US-20100267714-A1 | MIF MODULATORS | YALE UNIVERSITY | 2010-10-21 | — | — | US | disclosed |
| US-20100267714-A1 | MIF MODULATORS | YALE UNIVERSITY | 2010-10-21 | — | — | US | disclosed |
| US-20100267714-A1 | MIF MODULATORS | YALE UNIVERSITY | 2010-10-21 | — | — | US | disclosed |
| WO-2010021693-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584717-B2 | MIF modulators | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
| US-20200377457-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
| US-20180162813-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
| US-20120040974-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
| US-20120004261-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
| US-20100267714-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
| US-10202343-B2 | MIF modulators | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
| US-20190270706-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NPSR1 354/4885KDM4E 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.