Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043965 | 0.88 | KDM4E (0.52) | KDM4EHSD17B10MAPTNPSR1MEN1 | |
| SCHEMBL8394581 | 0.87 | GRM2 (0.52) | KDM4EHSD17B10ALDH1A1PPARGAGTR1 | |
| SCHEMBL8944506 | 0.87 | KDM4E (0.62) | KDM4EHSD17B10MAPTNPSR1MEN1 | |
| SCHEMBL8393163 | 0.87 | TP53 (0.57) | KDM4EMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL8395988 | 0.85 | DRD2 (0.54) | KDM4EMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL8394659 | 0.85 | PPARG (0.54) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL8391881 | 0.84 | ALDH1A1 (0.67) | KDM4EHSD17B10MAPTNPSR1MEN1 | |
| SCHEMBL8395491 | 0.83 | PPARG (0.54) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL8391700 | 0.83 | PPARG (0.54) | PPARGAGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL8391626 | 0.82 | ALDH1A1 (0.53) | KDM4EMAPTNPSR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |