Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.63 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.61 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.61 |
| ▸ | CTSD | P07339 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GUSB | P08236 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391622 | 0.88 | PPARG (0.69) | PPARGAGTR1AGTR2L3MBTL1KDM4E | |
| SCHEMBL9041351 | 0.86 | GRM2 (0.56) | PPARGAGTR1AGTR2CTSDL3MBTL1 | |
| SCHEMBL8394581 | 0.85 | GRM2 (0.52) | PPARGAGTR1AGTR2CTSDL3MBTL1 | |
| SCHEMBL8392673 | 0.85 | PPARG (0.66) | PPARGAGTR1AGTR2KDM4ECYP2C9 | |
| SCHEMBL8944506 | 0.85 | KDM4E (0.62) | PPARGAGTR1AGTR2KDM4ECYP2C9 | |
| SCHEMBL8393577 | 0.83 | PPARG (0.61) | PPARGAGTR1AGTR2GRM2KDM4E | |
| SCHEMBL8396864 | 0.83 | PPARG (0.72) | PPARGAGTR1AGTR2 | |
| SCHEMBL230485 | 0.83 | ALDH1A1 (0.66) | CTSDL3MBTL1KDM4ECYP2C9CYP1A2 | |
| SCHEMBL29411979 | 0.83 | ALDH1A1 (0.66) | CTSDL3MBTL1KDM4ECYP2C9CYP1A2 | |
| SCHEMBL8391717 | 0.82 | PPARG (0.71) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |