Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9036088 | 0.74 | KDM4E (0.45) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL2387265 | 0.72 | KDM4E (0.44) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL8944590 | 0.70 | KDM4E (0.45) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL9036092 | 0.69 | KDM4E (0.45) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL8944705 | 0.69 | TSHR (0.56) | KDM4ETDP1ALDH1A1POLBP2RX7 | |
| SCHEMBL8944840 | 0.69 | KDM4E (0.43) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL2656580 | 0.68 | KDM4E (0.88) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL29604869 | 0.66 | KDM4E (0.42) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL28368198 | 0.65 | CYP2A13 (0.43) | KDM4ETDP1ALDH1A1POLBCYP2A13 | |
| SCHEMBL593572 | 0.62 | CYP2A13 (0.66) | KDM4ETDP1ALDH1A1POLBCYP2A13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |