Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.61 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.59 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8391622 | 0.86 | PPARG (0.69) | PPARGAGTR1AGTR2ALDH1A1HSD17B10 | |
| SCHEMBL8392766 | 0.86 | ALDH1A1 (0.49) | PPARGAGTR1AGTR2ALDH1A1HSD17B10 | |
| SCHEMBL8392673 | 0.83 | PPARG (0.66) | PPARGAGTR1AGTR2ALDH1A1HSD17B10 | |
| SCHEMBL8396864 | 0.82 | PPARG (0.72) | PPARGAGTR1AGTR2 | |
| SCHEMBL8944521 | 0.81 | PPARG (0.63) | PPARGAGTR1AGTR2ALDH1A1HSD17B10 | |
| SCHEMBL8391717 | 0.80 | PPARG (0.71) | PPARGAGTR1AGTR2 | |
| SCHEMBL8394773 | 0.80 | PPARG (0.71) | PPARGAGTR1AGTR2 | |
| SCHEMBL8393562 | 0.80 | SMN1; SMN2 (0.73) | PPARGAGTR1AGTR2ALDH1A1HSD17B10 | |
| SCHEMBL8393577 | 0.80 | PPARG (0.61) | PPARGAGTR1AGTR2ALDH1A1HSD17B10 | |
| SCHEMBL8396012 | 0.79 | PPARG (0.80) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |