Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317019 | 0.76 | LMNA (0.59) | SIGMAR1POLBLMNAMEN1KMT2A | |
| SCHEMBL2458948 | 0.76 | LMNA (0.59) | SIGMAR1POLBLMNAMEN1KMT2A | |
| SCHEMBL8944584 | 0.76 | SIGMAR1 (0.47) | SIGMAR1LMNA | |
| SCHEMBL124097 | 0.74 | SIGMAR1 (0.59) | SIGMAR1POLBLMNAMEN1KMT2A | |
| SCHEMBL21315846 | 0.74 | SIGMAR1 (0.59) | SIGMAR1POLBLMNAMEN1KMT2A | |
| SCHEMBL65364 | 0.73 | SIGMAR1 (0.78) | SIGMAR1POLBLMNAMEN1KMT2A | |
| SCHEMBL7240012 | 0.73 | SIGMAR1 (0.58) | SIGMAR1POLBLMNAMEN1KMT2A | |
| SCHEMBL5561055 | 0.73 | SIGMAR1 (0.61) | SIGMAR1POLBLMNAGAA | |
| SCHEMBL5562968 | 0.73 | SIGMAR1 (0.61) | SIGMAR1POLBLMNAGAA | |
| SCHEMBL3343632 | 0.73 | SIGMAR1 (0.58) | SIGMAR1POLBLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | claimed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | claimed |
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |